Endpoints in Adjuvant Treatment Trials: A Systematic Review of the Literature in Colon Cancer and Proposed Definitions for Future Trials
Identifieur interne : 001474 ( Main/Exploration ); précédent : 001473; suivant : 001475Endpoints in Adjuvant Treatment Trials: A Systematic Review of the Literature in Colon Cancer and Proposed Definitions for Future Trials
Auteurs : Cornelis J. A. Punt [Pays-Bas] ; Marc Buyse ; Claus-Henning Khne ; Peter Hohenberger ; Roberto Labianca ; Hans J. Schmoll ; Lars Phlman ; Alberto Sobrero ; Jean-Yves DouillardSource :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 2007.
Abstract
Disease-free survival is increasingly being used as the primary endpoint of most trials testing adjuvant treatments in cancer. Other frequently used endpoints include overall survival, recurrence-free survival, and time to recurrence. These endpoints are often defined differently in different trials in the same type of cancer, leading to a lack of comparability among trials. In this Commentary, we used adjuvant studies in colon cancer as a model to address this issue. In a systematic review of the literature, we identified 52 studies of adjuvant treatment in colon cancer published in 19972006 that used eight other endpoints in addition to overall survival. Both the definition of these endpoints and the starting point for measuring time to the events that constituted these endpoints varied widely. A panel of experts on clinical research on colorectal cancer then reached consensus on the definition of each endpoint. Disease-free survivaldefined as the time from randomization to any event, irrespective of causewas considered to be the most informative endpoint for assessing the effect of treatment and therefore the most relevant to clinical practice. The proposed guidelines may add to the quality and cross-comparability of future studies of adjuvant treatments for cancer.
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DOI: 10.1093/jnci/djm024
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Other frequently used endpoints include overall survival, recurrence-free survival, and time to recurrence. These endpoints are often defined differently in different trials in the same type of cancer, leading to a lack of comparability among trials. In this Commentary, we used adjuvant studies in colon cancer as a model to address this issue. In a systematic review of the literature, we identified 52 studies of adjuvant treatment in colon cancer published in 19972006 that used eight other endpoints in addition to overall survival. Both the definition of these endpoints and the starting point for measuring time to the events that constituted these endpoints varied widely. A panel of experts on clinical research on colorectal cancer then reached consensus on the definition of each endpoint. Disease-free survivaldefined as the time from randomization to any event, irrespective of causewas considered to be the most informative endpoint for assessing the effect of treatment and therefore the most relevant to clinical practice. The proposed guidelines may add to the quality and cross-comparability of future studies of adjuvant treatments for cancer.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Buyse, Marc" sort="Buyse, Marc" uniqKey="Buyse M" first="Marc" last="Buyse">Marc Buyse</name><name sortKey="Douillard, Jean Yves" sort="Douillard, Jean Yves" uniqKey="Douillard J" first="Jean-Yves" last="Douillard">Jean-Yves Douillard</name><name sortKey="Hohenberger, Peter" sort="Hohenberger, Peter" uniqKey="Hohenberger P" first="Peter" last="Hohenberger">Peter Hohenberger</name><name sortKey="Khne, Claus Henning" sort="Khne, Claus Henning" uniqKey="Khne C" first="Claus-Henning" last="Khne">Claus-Henning Khne</name><name sortKey="Labianca, Roberto" sort="Labianca, Roberto" uniqKey="Labianca R" first="Roberto" last="Labianca">Roberto Labianca</name><name sortKey="Phlman, Lars" sort="Phlman, Lars" uniqKey="Phlman L" first="Lars" last="Phlman">Lars Phlman</name><name sortKey="Schmoll, Hans J" sort="Schmoll, Hans J" uniqKey="Schmoll H" first="Hans J." last="Schmoll">Hans J. Schmoll</name><name sortKey="Sobrero, Alberto" sort="Sobrero, Alberto" uniqKey="Sobrero A" first="Alberto" last="Sobrero">Alberto Sobrero</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Punt, Cornelis J A" sort="Punt, Cornelis J A" uniqKey="Punt C" first="Cornelis J. A." last="Punt">Cornelis J. A. Punt</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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